Abstract
Polycystic ovary syndrome (PCOS) is commonly associated with endocrine, metabolic, cardiovascular and other morbidities. However its association with autoimmune diseases is still controversial. The aim of this study was to assess the prevalence of non organ-specific and antithyroid, antibodies in PCOS women compared to healthy controls. The study included 152 women with PCOS and 76 healthy controls for the evaluation of non organ-specific autoimmunity and 64 PCOS and 68 controls for the study of organ-specific autoimmunity. All sera were tested for autoantibodies.using the ELISA method. There were no significant differences in the prevalence of ANA, SSA, SSB, anti-dsDNA, anti-RNP, ANCA/MPO or ANCA/PR3 between PCOS and controls. The prevalence of ACLA IgG was higher in controls than PCOS (5.4% v.s. 0%, P=0.011). Patients had a higher prevalence of anti-TPO antibodies (18.75% v.s. 7.35%, P=0.045) and slightly but not significantly higher prevalence of autoimmune thyroiditis (18.75% v.s. 10.29%) than controls. The prevalence of non organ-specific autoantibodies in PCOS women is low and similar to controls. On the other hand, we found a slightly higher prevalence of thyroid autoimmunity in PCOS women.
Highlights
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of child-bearing age
PCOS women had significantly higher BMI compared to controls (28.08 + 6.91 v.s 21.31 + 3.05, P
There were no significant differences in the prevalence of ANA screening, SSA/Ro, SSB/La, anti RNP, anti ds-DNA between PCOS and control women, which was very low in both groups
Summary
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of child-bearing age. It is typically identified during the early reproductive years or adolescence and its prevalence is as high as 15% when the broader Rotterdam criteria are applied[1] and about 10% according to the criteria of the Androgen Excess Society (AES) (ref.[2]). Polycystic ovary syndrome (PCOS) is commonly associated with endocrine, metabolic, cardiovascular and other morbidities. Aim. The aim of this study was to assess the prevalence of non organ-specific and antithyroid, antibodies in PCOS women compared to healthy controls. The prevalence of non organ-specific autoantibodies in PCOS women is low and similar to controls. We found a slightly higher prevalence of thyroid autoimmunity in PCOS women
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