Abstract
Previous studies found that hypertension and high homocysteine (HHcy) exhibited a synergistic effect on the risk of cardiovascular diseases. This study aimed to investigate the prevalence of hypertension accompanied by HHcy and its risk factors in the rural areas of northeast China. This study was conducted using a stratified cluster random sampling method, and included 6529 subjects with complete data. Demographic characteristics were obtained from a questionnaire. Blood pressure and anthropometric indices were measured, and serum indices were analyzed. Hypertension accompanied by HHcy was defined as hypertension plus HHcy [homocysteine (Hcy) > 10 µmol/L]. The mean concentration of Hcy was 17.29 μmol/L in the general population. The prevalence of hypertension accompanied by HHcy was so high that it reached 45.1% of our study population and accounted for 86.8% of the total participants with hypertension. Multiple logistic regression analysis indicated that the modifiable risk factors of hypertension accompanied by HHcy included obesity, diabetes, dyslipidemia, and inactive physical activities. We found that the mean level of Hcy, and the prevalences of HHcy and hypertension accompanied by HHcy were very high among the rural population of northeast China. Obesity, diabetes, dyslipidemia, and inactive physical activities were modifiable risk factors of hypertension accompanied by HHcy.
Highlights
Hypertension has been identified as an independent risk factor of cardiovascular diseases (CVD)and is the number one cause of deaths all over the world [1]
Multiple logistic regression analysis indicated that the modifiable risk factors of hypertension accompanied by high homocysteine (HHcy) included obesity, diabetes, dyslipidemia, and inactive physical activities
Diabetes, dyslipidemia, and inactive physical activities were modifiable risk factors of hypertension accompanied by HHcy
Summary
Hypertension has been identified as an independent risk factor of cardiovascular diseases (CVD)and is the number one cause of deaths all over the world [1]. Hypertension is becoming a global epidemic in both children and adults, in both the rural population and urban population [2,3]. The Report indicated that approximately one in five Chinese (about 270 million) individuals suffered from hypertension and that mortality due to hypertension accounted for 2.04 million cases, representing 24.6% of the total number of deaths. According to the Reports on Nutrition and Chronic Disease Status of Chinese Residents (2015) [5], the prevalence of hypertension was 25.2% in adults aged ≥ 18 years. Our previous study based on subjects ≥ 35 years found that the prevalence of hypertension was so high that it reached 51.1% in the rural population of northeast China [3]. It was worth noting that about 75% of hypertensive patients exhibited high homocysteine (HHcy) in China [6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
