The prevalence of human papillomavirus genotypes (HPV-6, HPV-11, HPV-16, and HPV-18) in the unilateral and bilateral nasal polyps

Abstract

Aim The aim of this study was to investigate the prevalence of different genotypes (HP-6, HP-11, HP-16, and HP-18) of human papillomavirus (HPV) in nasal polyps (NPs). Materials and methods This is a prospective, comparative, controlled study. A total of 24 patients with NPs along with 10 patients with deviated nasal septum without NPs (as controls) were enrolled. Biopsy specimens from the patients’ NPs and from nasal mucosa of controls were collected for the detection of the four HP genotypes using PCR-based DNA amplification using the genotype-specific primers (6/E5, 11/L1, 16/L1, and 18/L1). Results An overall 91% (22/24) of patients with NPs were found to be positive for HPV infection, whereas all participants of the control group were negative (P Conclusion Our findings suggest that the HPV infection is associated with the formation of NPs and further investigation is imperative to define a correlation between the two.