Abstract
BackgroundThe natural history of human papillomavirus (HPV) is influenced by vaginal microenvironment disorders, such as bacterial vaginosis (BV). The objective of this study was to assess the epidemiology of HPV combined with BV prevalence among Chinese women aged 20–35 years.MethodsA total of 2000 sexually active women aged 20–35 years voluntarily enrolled in this study and underwent a ThinPrep cytologic test and PCR-reverse dot blot human papillomavirus genotyping (PCR-RDB HPV test). BV was diagnosed if clue cells were observed (20% more than epithelial cells).ResultsThe overall HPV infection rate in this population was 16.2% (324/2000). Compared with HPV-negative individuals, BV prevalence was higher in the High-risk human papillomavirus (HR-HPV) (5.9% vs. 3.1%, P < 0.001). BV and HPV-51, -52 infection were more commonly associated with each other. In patients with cervical lesions (≥ CIN 1), the BV prevalence rate was higher than in patients with negative for intraepithelial lesion or malignancy (NILM) (11.9% vs. 3.8%, P = 0.002).ConclusionBV was found to be related to HPV-51, -52 infections and cervical lesions. To better manage HPV infected population, more attention should be paid to the prevention and proper treatment of BV.
Highlights
Cervical cancer is the fourth most frequently occurring cancer among women worldwide and is common in resource-limited countries
This study cohort consisted of 2000 women who were subject to human papillomavirus (HPV) testing and cytology screening
HPV types targeted by bivalent HPV vaccine (HPV-16/18) were 13.9% (45/324, 95% confidence intervals (CIs) 10.12–17.65), by quadrivalent vaccine (HPV-6/11/16/18) were 17.9% (58/324, 95% CI 13.73–22.08), by nonavalent vaccine (HPV6/11/16/18/31/33/45/52/58) were 50.0% (162/324, 95% CI 44.56–55.44) in HPV positive women
Summary
Cervical cancer is the fourth most frequently occurring cancer among women worldwide and is common in resource-limited countries. Cervical cancer mostly occurs in women aged 30–39 and 60–69 years, one study suggested that cervical cancer in the young tends to be more aggressive [5]. China is the largest resource-limited country, and compared with regular cervical cancer screening, vaccination against HPV may be useful and effective. The vaccination rate remains low and all available vaccines are currently developed based on epidemiological data from Western countries. These vaccines may not archive the desired efficiency and it is essential to develop policies on how to apply HPV vaccination to cervical cancer control programs in targeting Chinese women. The objective of this study was to assess the epidemiology of HPV combined with BV prevalence among Chinese women aged 20–35 years
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