Abstract
Objective: to evaluate the clinical and epidemiological features of chronic adenoiditis and adenotonzillitis in children with nasopharyngeal carriage of the Epstein-Barr virus, cytomegalovirus and human herpesvirus 6. We conducted open comparative study, which involved 200 patients undergoing conservative and surgical treatment (adenotomy, adenotonzillotomy) at the ENT department of the Medical Center “Mart” (Kazan).Results. We obtained positive result of herpesvirus test in 65% (95% CI 58.4–71.6), 130/200 cases. There were registered 92 cases of the Epstein-Barr virus infection (70.8% [95% CI 63–78.6]), 46 – cytomegalovirus (35.4% [95% CI 27.2–43.6]) and 56 – human herpesvirus 6 (43.1% [95% CI 34.6–51.6]). 100% of patients with herpesvirus 6 had recurrent respiratory diseases, an increase in the cervical group of lymph nodes; 36.4% (95% CI 16.4–56.4%), 8/22 of these patients did not need operative treatment. Patients with the Epstein-Barr virus, cytomegalovirus and their combination more often complained of hypertrophy of the pharyngeal tonsil, recurrent otitis and a decrease in hearing, p<0.01. Patients with Epstein-Barr virus infection (11.9% [95% CI 2.2–21.6]), 5/42) were more often dissatisfied with the treatment results.Conclusion: effective options of treatment and prevention of hypertrophy of the lymphoid tissue of the pharyngeal ring should include etiotropic therapy of herpesvirus infections.
Highlights
Ключевые слова: дети, аденоиды, гипертрофия глоточной и небных миндалин, герпесвирусы, Эпштейна–Барр вирус, цитомегаловирус, вирус герпеса человека 6 типа
We obtained positive result of herpesvirus test in 65%, 130/200 cases
There were registered 92 cases of the Epstein-Barr virus infection (70.8% [95% CI 63–78.6]), 46 – cytomegalovirus (35.4% [95% CI 27.2–43.6]) and 56 – human herpesvirus 6 (43.1% [95% CI 34.6–51.6]). 100% of patients with herpesvirus 6 had recurrent respiratory diseases, an increase in the cervical group of lymph nodes; 36.4%, 8/22 of these patients did not need operative treatment
Summary
Распространенность герпесвирусных инфекций у детей с гипертрофией глоточной миндалины. Цель работы: оценить клинико-эпидемиологические особенности хронических аденоидитов и аденотонзиллитов у детей с носоглоточным носительством вируса Эпштейна–Барр, цитомегаловируса и вируса герпеса человека 6-го типа. Patients with Epstein-Barr virus infection (11.9% [95% CI 2.2–21.6]), 5/42) were more often dissatisfied with the treatment results. В этом контексте широкая распространенность, способность к длительной персистенции в клетках слизистой оболочки верхних дыхательных путей, крови и лимфоидной ткани актуализируют проблему герпесвирусных инфекций при патологии лимфоглоточного кольца. [6] показано, что вирус Эпштейна–Барр, наряду с другими респираторными вирусами, статистически значимо чаще выделяли у детей с клиникой аденоидитов и гипертрофией глоточной миндалины. Цель исследования: оценить клинико-эпидемиологические особенности хронических аденоидитов и аденотонзиллитов у детей с носоглоточным носительством Эпштейна–Барр-вирусной, цитомегаловирусной и ВГЧ-6*-вирусной инфекций
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