The prevalence of Helicobacter Pylori infection in patients with obstructive sleep apnea having metabolic syndrome and its relation to both disorders

Laila A H Banawan,Mona Mohamed Tolba ,Wafaa H Elsheikh ,Rasha Daabis ,Amira M Youssef

doi:10.4103/ejb.ejb_54_16

Laila A H Banawan, Mona Mohamed Tolba + Show 3 more

Open Access

https://doi.org/10.4103/ejb.ejb_54_16

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Journal: Egyptian Journal of Bronchology	Publication Date: Jul 24, 2017
Citations: 1	License type: open-access

Affiliation: Alexandria University

Abstract

IntroductionObstructive sleep apnea hypopnea syndrome (OSAHS) is a highly prevalent respiratory disorder and is associated with metabolic syndrome (MS). Helicobacter pylori (H. pylori) infection (Hp-I)maybe involved in the pathogenesis of both obstructive sleep apnea (OSA) and gastroesophageal reflux disease(GERD);the latter is alsoassociatedwithOSAHS. Anassociation betweenHp-IandOSAhas beenreportedas well as a potential association between Hp-I and insulin resistance, which represents the pathogenetic basis of MS.ObjectiveTo study the prevalence of Hp-I in patients with OSAHS having MS and its relation to both OSAHS and MS and to asses GERD symptoms in the studied groups and its relation to the severity of OSA and to Hp-I.Patients and methodsThis study included 28 patients with confirmed OSAHS by overnight polysomnography, with half of them having MS. Demographic, comorbidities, anthropometric, and clinical data were collected. Stool analysis for H. pylori antigen was done.ResultsPatients with OSAHS with MS had significantly more severe OSA (P≤0.001*). The prevalence of both Hp-I and GERD was significantly higher in the MS group (P=0.023 and 0.018, respectively). GERD was significantly associated with H. pylori infection in the studied groups (P<0.001). The prevalence of Hp-I and GERD increased with the severity of OSAHS, but it did not reach statistical significance, as in patients with mild, moderate, and severe OSAHS, the prevalence of Hp-I and GERD was 16.7, 50, and 64.3%, respectively, and 12.5, 25, and 62.5%, respectively.ConclusionH. pylori infection can be considered as a potential confounder involved in OSAHS and GERD pathophysiology associated with MS. Egypt J Bronchol 2017 11:268–275

Highlights

Obstructive sleep apnea hypopnea syndrome (OSAHS) is a highly prevalent respiratory disorder and is associated with metabolic syndrome (MS)
The prevalence of Hp-I and gastroesophageal reflux disease (GERD) increased with the severity of OSAHS, but it did not reach statistical significance, as in patients with mild, moderate, and severe OSAHS, the prevalence of Hp-I and GERD was 16.7, 50, and 64.3%, respectively, and 12.5, 25, and 62.5%, respectively
This study revealed that BMI, neck circumference (NC), and waist circumference (WC) were significantly higher in patients with OSAHS having MS

Summary

Introduction

Obstructive sleep apnea hypopnea syndrome (OSAHS) is a highly prevalent respiratory disorder and is associated with metabolic syndrome (MS). Obstructive sleep apnea hypopnea syndrome (OSAHS) is an important medical condition whose prevalence is estimated to range from 3 to 7%, which can increase in some subgroups of population. It is an important cause of morbidity and mortality worldwide. The metabolic syndrome (MS) is an emerging public health concern [2] It includes several interrelated risk factors of metabolic origin that increase the risk for developing coronary artery disease (CAD), stroke, and diabetes, owing to its underlying associated proinflammatory and prothrombotic states [3]. It includes the typical features of the MS (Syndrome X), which are central obesity, diabetes, hypertension, and dyslipidemia, with the addition of obstructive sleep apnea (OSA) [4]

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