Abstract
Vibrio cholerae live in aquatic environments and cause cholera disease. Like many other bacteria, V. cholerae use quorum-sensing (QS) systems to control various cellular functions, such as pathogenesis and biofilm formation. However, some V. cholerae strains are naturally QS-defective, including defective mutations in the quorum sensing master regulator HapR. Here we examined the QS functionality of 602 V. cholerae clinical and environmental strains isolated in China from 1960-2007, by measuring QS-regulated gene expression. We found that a greater percentage of the toxigenic strains (ctxAB(+)) had functional QS as compared to the non-toxigenic strains (ctxAB(-)), and that this trend increased significantly over time. We hypothesize that QS provides adaptive value in V. cholerae pathogenic settings.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
