Abstract
BackgroundDiabetes mellitus has become a major health issue in the United States and contributes to morbidity and mortality from coronary artery disease. Despite lifestyle changes and medications that have been shown to decrease complications and death, many persons have poor glycemic control. The purpose of this study is to determine the prevalence of elevated Hemoglobin A1c levels, a marker of glycemic control in patients presenting for coronary artery bypass surgery, and to determine if risk factors for diabetes mellitus could identify those patients with an elevated hemoglobin A1c.MethodsAll patients undergoing coronary artery bypass surgery had hemoglobin A1c levels determined immediately preoperatively. Proportions were used to describe the number of patients with elevated levels. Linear regression and receiver operator characteristic curves were used to evaluate the accuracy of risk factors to identify patients with elevated levels.Results83 of 87 (95%) diabetic patients had elevated A1c levels (≥ 6.0%), with 55 of 87 (63%) having inadequate control – A1c levels ≥ 7.0. 93 of 163 (57%) non-diabetic patients had elevated A1c levels (≥ 6.0%), with 19 (12%) having levels ≥ 7.0%. Risk factors for diabetes mellitus poorly predicted which patient had elevated A1c levels.ConclusionThe prevalence of elevated hemoglobin levels in patients undergoing coronary artery bypass surgery is high and routine measurement should be done to permit institution of lifestyle modifications and medication changes that decrease complications and death from diabetes mellitus.
Highlights
Diabetes mellitus has become a major health issue in the United States and contributes to morbidity and mortality from coronary artery disease
hemoglobin A1c (HbA1c) is the glycosolated form of hemoglobin and its level is proportional to the average glucose level over the past 2–3 months [7]
While not recommended for the diagnosis of DM [8], specific HbA1c levels are recommended as treatment goals by national organizations [9,10] and we used these levels in guiding post-discharge therapy and instructions
Summary
Diabetes mellitus has become a major health issue in the United States and contributes to morbidity and mortality from coronary artery disease. The purpose of this study is to determine the prevalence of elevated Hemoglobin A1c levels, a marker of glycemic control in patients presenting for coronary artery bypass surgery, and to determine if risk factors for diabetes mellitus could identify those patients with an elevated hemoglobin A1c. To better help us provide for patients' post-discharge care, we began to routinely check hemoglobin A1c (HbA1c). The purpose of this study was to determine the prevalence of elevated HbA1c in the diabetic and non-diabetic subcohorts of a cardiac surgery population and to determine if age, height, weight, and body mass index – standard risk factors for DM could be used to predict elevated HbA1c levels
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