The prevalence of colistin-resistant Gram-negative bacteria isolated from hospitalized patients with bacteremia

doi:10.7324/japs.2020.102009

Abstract

Highlights

Colistin, called polymixin E, plays an important role as the last line of anti-Gram-negative defense against multidrug resistant (MDR) pathogens, carbapenemresistant Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacteriaceae
This study sought to investigate the prevalence of colistin-resistant Gram-negative bacteria (CoR-GNB) among Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae isolated from patients with bacteremia and to identify other antimicrobials as a potential therapy for CoR-GNB infections
During the 1-year study period, 623 studied bacterial isolates were obtained from blood cultures including 349 E. coli isolates, 150 K. pneumoniae isolates, 60 A. baumannii isolates, and 64 P. aeruginosa isolates

Summary

Introduction

Called polymixin E, plays an important role as the last line of anti-Gram-negative defense against multidrug resistant (MDR) pathogens, carbapenemresistant Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacteriaceae. Colistin is not a new agent; it has been used since the early 1950s. Some organisms have intrinsic colistin resistance, including Serratia marcescens, Proteus spp., Providencia spp., Morganella morganii, Burkholderia cepacia, and Vibrio cholera (Sherry and Howden, 2018). Because of increasing colistin consumption, organisms that have acquired colistin resistance via chromosomal genes or plasmids have been globally reported. Colistin resistance among non-inherent resistant bacteria in Enterobacteriaceae has a prevalence of approximately 0.67%–1.6%, with high rates in Enterobacter spp. For non-fermentative Gram-negative bacteria, the rates of colistin-resistant A. baumannii in the global SENTRY Colistin resistance among non-inherent resistant bacteria in Enterobacteriaceae has a prevalence of approximately 0.67%–1.6%, with high rates in Enterobacter spp. (13.9%–20.1%), followed by K. pneumoniae (1.5%–6.8%) and E. coli (0.2%–0.6%) (Sherry and Howden, 2018).

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Conclusion