THE PREVALENCE OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH ARTERIAL HYPERTENSION

Abstract

Objective: To study the prevalence of chronic kidney disease (CKD) markers in patients with arterial hypertension(AH). Design and method: Retrospective analysis of 188 case histories of patients with AH of 1-3 degrees (ESC/ESH, 2018) who received inpatient treatment was carried out. 109 women and 79 men were studied. Mean age 62.8 ± 10.2 years. CKD stages were established according the modern KDIGO 2013 classification. Results: Among the examined patients there were 18% patients with CKD 1(n = 34); 56.3% patients with CKD 2 (n = 106); 17.5% patients with CKD 3A(n = 33); 5.3% patients with CKD 3B (n = 10); 2.6% patients with CKD 4 (n = 5) (p<0.00001). It should be noted that patients with stage 4 CKD were significantly older (55±8 vs 62±9 vs 68±8 vs 69±9 vs 74±16; p = 0.00001). According to the level of SBP, DBP, heart rate, the patients did not differ significantly. SBP (p = 0.26). DBP (p = 0.25). Patients with stage 4 CKD had severe abdominal obesity. WC: 102.4 ± 10 vs 104.7 ± 13.6 vs 103.2 ± 10.7 vs 101.5 ± 12.4 vs 110 ± 27.3 (p = 0.68). Mean creatinine in the groups was 70.6 ± 14.7 vs 85.2 ± 14.4 vs 102.3 ± 14.6 vs 121.6 ± 25.3 vs 209.6 ± 45.5 (p<0.00001) . Mean eGFR 98.2 ± 7.3 vs 72.9 ± 7.4 vs 53.7 ± 4.2 vs 37.5 ± 4.1 vs 22.6 ± 3.8 p (p<0.00001). The analysis showed that as the stage of CKD increases, the level of microalbuminuria increases. Thus, MAU indicators were 31.05 ± 25.5 vs 41.6 ± 50.2 vs 38.6 ± 46 vs 96.6 ± 144.7 vs 308.8 ± 147.5 (p<0.00001). It should be noted, that the high stages of CKD are characterized by significantly more pronounced asymptomatic hyperuremia. At the same time, the level of uric acid in group I was 5.4 ± 1.4 vs 6.5 ± 4.7 vs 6.5 ± 1.7 vs 7.5 ± 1.7 vs 7.8 ± 1.01 (p <0.00001). Conclusions: Among patients with hypertension, the prevalence of CKD is significantly high (82%), which additionally increases the cardiovascular risk of this category of patients.