Abstract
In this study, we investigate the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China. From January to April 2020, 38,144 healthy blood donors in the three cities were tested for total antibody against SARS-CoV-2 followed by pseudotype SARS-CoV-2 neutralization tests, IgG, and IgM antibody testing. Finally, a total of 398 donors were confirmed positive. The age- and sex-standardized SARS-CoV-2 seroprevalence among 18–60 year-old adults (18–65 year-old in Shenzhen) was 2.66% (95% CI: 2.24%–3.07%) in Wuhan, 0.033% (95% CI: 0.0029%–0.267%) in Shenzhen, and 0.0028% (95% CI: 0.0001%–0.158%) in Shijiazhuang, respectively. Female sex and older-age were identified to be independent risk factors for SARS-CoV-2 seropositivity among blood donors in Wuhan. As most of the population of China remained uninfected during the early wave of the COVID-19 pandemic, effective public health measures are still certainly required to block viral spread before a vaccine is widely available.
Highlights
In this study, we investigate the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China
We systematically investigated the SARS-CoV-2 seroprevalence among large cohorts of healthy blood donors from different cities in mainland China
Wuhan is the earliest COVID-19affected city and had most of the reported COVID-19 patients in China, the SARS-CoV-2 antibody presence was only noted in 2.22% of 17,794 blood donors (2.66% after age–sex standardization) during January–April 2020
Summary
We investigate the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China. Only limited information on serologic screening of specific asymptomatic people showed that seroprevalence of SARS-CoV-2 varied from 1.6% to 4.1% among different countries and populations[15,16,17]. We investigated the prevalence of SARS-CoV-2 antibodies among donors who donated their blood from January to April 2020 in the cities of Wuhan, Shenzhen, and Shijiazhuang. These three different cities, locating in the central, south, and north of China, have similar population size but of distinct COVID-19 incidence. The potential risk factors for SARS-CoV-2 seropositivity were analyzed
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