The prevalence of allergy to fish in children in Tomsk region

Abstract

Objective. To investigate the prevalence and clinical manifestations of FA to fish in children in Tomsk region. Patients and methods. In the screening stage the crosssectional study based on screening questionnaires in random samples of children aged 7-10 years (n=13 010) was performed as a part of EuroPrevall project (EuroRrevall, № FP62006TTCTU5 Proposal 045 879). Those, who reported adverse reactions to food in the screening stage were considered as cases (n=652), children without reported reactions were controls (n=636). The casecontrol stage included the completion of a clinical questionnaire, skinprick test to fish (ALK Abellö, Spain), measurement of serum total and specific IgE to fish, componentresolved diagnostics: Cyp c 1, Gad m 1 (ImmunoCAP, ISAC, Phadia, Sweden). Results. The prevalence of verified FA to fish in children 7-10 years in the Tomsk region amounted to 0,32%; in urban children - 0,32%, in rural children - 0,31% (p=0,9). The main manifestations were skin symptoms, oral allergy syndrome, gastrointestinal symptoms. Anaphylactic shock developed in 15% of children with FA to fish. Conclusion. Fish is one of the main triggers of FA in children in Tomsk region, which leads to severe clinical manifestations , including lifethreatening conditions.