Abstract
The prevalence and risk of missing outcome data in prenatal vitamin D supplemented gestational diabetes mellitus patients: a systematic review and meta-analysis protocol
Highlights
Missing outcome data in clinical trials are important determinants of internal validity; its burden and risk in gestational diabetes mellitus (GDM) mothers supplemented with vitamin D remain poorly studied
Several trials have tested the effects of antenatal vitamin D supplementation on GDM mothers and their infants; it is not clear if missing outcome data threatens these trials' internal validity meta-analyses that abstract data from these
A systematic review protocol is proposed here to determine the prevalence of missing outcome data in vitamin D supplemented GDM mothers and compare its risk with placebo recipients
Summary
Missing outcome data in clinical trials are important determinants of internal validity; its burden and risk in gestational diabetes mellitus (GDM) mothers supplemented with vitamin D remain poorly studied. Gestational diabetes mellitus (GDM) is a medical complication of pregnancy. It manifests as glucose intolerance (of any degree) that is detected or developed for the first time during pregnancy [1]. With the rising trend in obesity and a sedentary lifestyle, its prevalence in reproductive age group females is increasing globally [2]. GDM’s complications can affect both the mother and her neonate. Maternal complications may include an increased risk of type 2 diabetes development, cesarean section, pre-eclampsia, and polyhydramnios [1,3,4]. Some of the fetal complications include newborn
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