THE PREVALENCE AND PATIENT CHARACTERISTICS OF ASTHMA-COPD OVERLAP SYNDROME AMONG CHRONIC AIRFLOW LIMITATIONS PATIENTS: HOSPITAL-BASED STUDY

Abstract

SESSION TITLE: Tuesday Abstract Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/22/2019 01:00 PM - 02:00 PM PURPOSE: Distinguishing asthma from COPD can be problematic, particularly in smokers and older adults. Asthma-COPD overlap syndrome (ACOS) is identified by the clinical features that it shares with both asthma and COPD. In epidemiological studies, reported prevalence rates for ACOS have wide range between 15-20% reflects the different criteria that have been used by different investigator for diagnosing ACOS. Moreover, there is still no data about ACOS prevalence in Indonesia. Therefore, we aimed to determine prevalence and patient characteristics of ACOS among chronic airflow limitations patients in Indonesia. METHODS: This hospital-based cross sectional study conducted in asthma and COPD patients. Patients were male or female, 40 years or older and able to perform a spirometry and bronchodilator test. ACOS diagnosis was made using modified GINA/GOLD 2017 criteria which at least three clinical features that support asthma and COPD. RESULTS: This study showed that ACOS prevalence from 60 subjects was 58.3%. Characteristic patients identified as having ACOS had mean age of 61.5±10.2 year, median Brinkman index 0.5, mean BMI of 24.9±3.8% kg/m2 and the most common symptoms were shortness of breath (88.7%) and wheezing (77.1%). Spirometry result showed better lung function with variability was 10.1% and increase in forced expiratory volume in 1 second (FEV1) 158.3±97.2 ml after bronchodilator test. Chest radiograph from ACOS patient showed 48.6% had severe hyperinflamation. CONCLUSIONS: The prevalence of ACOS was high in hospital based using GINA/GOLD criteria among asthma and COPD patients. To manage ACOS patients effectively it is necessary to identify it accurately. CLINICAL IMPLICATIONS: This results may have an clinical implication on the early identification of ACOS and to manage patients for the most appropriate therapy. DISCLOSURES: No relevant relationships by Triya Damayanti, source=Web Response No relevant relationships by Rania Imaniar, source=Web Response no disclosure on file for Faisal Yunus