Abstract
BackgroundGall stones are the most common biliary pathology. Subclinical hypothyroidism is not a common problem in the population with thyroid disease, several explanations for a possible relation between hypothyroidism and lipid metabolism, gall stone formation proved that prevalence of gall stones is increased in patients with hypothyroidism disease.ObjectiveTo find the prevalence and correlation between the subclinical hypothyroidism and gall stone disease.MethodsThis cross-sectional study in Baghdad teaching hospital which done over the period of January 2015 till December 2015 where 103 patients presented with gall stones as an in and outpatients. All the patients were assessed and prepared for cholecystectomy by detailed history, clinical examination, thyroid function test and abdominal ultrasound.ResultsAmong 103 patients, the majority them were in 36–50 years age group, 84 (81.6%) of them were females and 19 (18.4%) were males. Of the total number of patients, eight of them (7.8%) found to have subclinical hypothyroidism and 95 (92.2%) of them found to be euthyroid, most of patients in the subclinical hypothyroid group were showing female gender predominance with 81.6%. While the prevalence among males were found 18.4%, most patients with subclinical hypothyroidism were found to had positive family history (75%), and (25%) of them found to had negative family history.ConclusionThere is gender specific relationship between subclinical hypothyroidism and gall stone disease as this study sharing statistically increasing in prevalence of the subclinical hypothyroidism among females in age group ≥ 40 years, positive family history, and single abdominal US gall stone. This subset of patients should be assessed for thyroid dysfunction.
Highlights
Gall stones: Gall stones are the most common biliary pathology, recent studies show that 10–15% of adult population in USA has gall stones (20 millions), 3% of them underwent cholecystectomy, 85% of them asymptomatic, 1–4% of them develop symptoms each year, females more affected than males 3:1 [1,2].The hypothyroidism can be either a subclinical type or hypothyroidism where the level of thyroxine is below normal.Subclinical hypothyroidism is identified when serum thyroid hormones are within normal lab level, but serum thyroid stimulating hormone (TSH) level is slightly raised [3]
This is a cross-sectional study performed at Baghdad teaching hospital over the period from January 2015 till December 2015, where 103 patients presented with gall stones, had been checked for concomitant presence of subclinical hypothyroidism
Subclinical hypothyroidism is a predominant disorder among adult population; it is often overlooked
Summary
Gall stones (cholelithiasis): Gall stones are the most common biliary pathology, recent studies show that 10–15% of adult population in USA has gall stones (20 millions), 3% of them underwent cholecystectomy, 85% of them asymptomatic, 1–4% of them develop symptoms each year, females more affected than males 3:1 [1,2].The hypothyroidism can be either a subclinical type or hypothyroidism (overt) where the level of thyroxine is below normal.Subclinical hypothyroidism (mild thyroid failure) is identified when serum thyroid hormones are within normal lab level, but serum thyroid stimulating hormone (TSH) level is slightly raised [3]. Subclinical hypothyroidism is not a common problem in the population with thyroid disease, several explanations for a possible relation between hypothyroidism and lipid metabolism, gall stone formation proved that prevalence of gall stones is increased in patients with hypothyroidism disease. Conclusion: There is gender specific relationship between subclinical hypothyroidism and gall stone disease as this study sharing statistically increasing in prevalence of the subclinical hypothyroidism among females in age group ≥ 40 years, positive family history, and single abdominal US gall stone. This subset of patients should be assessed for thyroid dysfunction
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