Abstract
Irritable bowel syndrome (IBS) is a common chronic disorder characterized by recurrent abdominal pain, bowel movement changes, diarrhea, constipation, or both and affect approximately 10-20% of the general population. Today, IBS is considered a disorder of dysregulation of the so called brain-gut axis and evidence also suggests that gastrointestinal inflammation may be of great importance in the majority of cases of IBS. In addition to gastrointestinal symptoms, many patients have atopic symptoms. The aim of this study was to study the prevalence of atopic manifestations in volunteers with IBS in a Brazilian urban community. Volunteers over 18 years of age were enrolled and evaluated. The participants were evaluated by a gastroenterologist of the Group of Study of Intestinal Diseases at Hospital Universitario Antonio Pedro. All volunteers were evaluated to determine if patients had symptoms compatible with the diagnosis of IBS based on Rome III criteria. The identification of the atopic manifestations was based in a structured questionnaire for atopy. Three hundred and fifty volunteers were enrolled. Of them, 330 volunteers were evaluated: 78 (23.6%) of the volunteers had symptoms compatible with IBS (Group I) and 252 (76.3%) without symptoms compatible with IBS (Group II). Atopic manifestations were present in 46 (65.3%) in Group I and 105 (41. 0%) in Group II (P=0.0107, OR-2.01 95%CI -1. 20-3. 37). The association between atopic manifestations and the presence of IBS was relevant in patients in this Brazilian urban community. This fact may have implications for diagnosis and treatment of patients with IBS.
Highlights
Irritable bowel syndrome (IBS) affects 10-Correspondence: Rosa L.S
This paper aims to an institutional review board (IRB)-approved information sheet that them, 330 volunteers were evaluated: 78 study the prevalence of atopic manifestations described the purpose of the study, the volun
This fact may in Niterói, RJ, Brazil were enrolled during a 2- III criteria for IBS
Summary
The aim of this study was to o study the prevalence of atopic manifestations in volunteers with IBS in a Brazilian urban. The volunteers were selected from students and employees of the Federal Fluminense University, Faculty of Medicine, Computer Science and Social Sciences, Niterói, RJ, Brazil They were recruited through a poster affixed on the door of the Group of Study of Intestinal Diseases (Outpatients Unit), Hospital Universitário Antonio Pedro. The volunassociation between atopic manifestations and teers went through a complete clinical evaluathe presence of IBS was relevant in patients in Adult volunteers aged 18 and over, residents tion. Diagnosis of IBS was based on the Rome this Brazilian urban community This fact may in Niterói, RJ, Brazil were enrolled during a 2- III criteria for IBS. Discussion positive responses to a skin prick test for food antigens was significantly greater in a D-IBS group of patients than in the other two groups
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