Abstract
The lymphocyte-to-monocyte ratio (LMR) has been reported to predict clinical outcomes in multiple malignancies. The aim of this study was to assess the prognostic role of pretreatment LMR in hepatocellular carcinoma (HCC). A total of seven studies comprising 2,738 patients were included in the meta-analysis. Pooled results showed that elevated LMR was significantly associated with increased overall survival (OS) (HR: 0.31, 95% CI: 0.20–0.47, p < 0.001), disease-free survival (DFS)/recurrence-free survival (RFS) (HR: 0.57, 95% CI: 0.49–0.67, p < 0.001). The favorable prognostic impact of high LMR on OS was observed in all subgroup with different sample size, type of publication, NOS score, and the cut-off value of LMR. In addition, low LMR was significantly correlated with TNM stage and BCLC stage. We therefore conclude that elevated pretreatment LMR could be a favorable prognostic factor for clinical outcomes in patients with HCC.
Highlights
There has been no meta-analysis to assess the correlation between pretreatment LMR and the survival of hepatocellular carcinoma (HCC) patients
The criteria for inclusion were listed as follows: (1) the diagnosis of HCC were confirmed by pathology; (2) studies assessing the association of pretreatment LMR with OS, DFS/RFS, or CSS; (3) the cut-off value of LMR was reported; and (4) studies supplied sufficient information for calculating hazard ratio (HR) and 95% confidence interval (CI)
Mounting studies indicated that infiltration of inflammatory cells in the tumor microenvironment significantly affected the biological behavior of HCC25
Summary
The aim of this study was to assess the prognostic role of pretreatment LMR in hepatocellular carcinoma (HCC)
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