Abstract
In amphibian sympathetic ganglia, a transient membrane depolarization was produced at the intraganglionic portion of preganglionic nerve fibers when ganglion cells were activated antidromically. Such a depolarization was produced by the action of a chemical transmitter which was not acetylcholine but an unidentified substance released from some cellular elements in the ganglion. These results suggested that the preganglionic nerve terminals possess some noncholinergic receptors in addition to the cholinergic presynaptic receptors.
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