The Presentation of Therapeutic Effect Of Memantine in Sepsis Induced Critical Illness Polyneuropathy

Abstract

BACKGROUND: The purpose of our study is to investigate the effects of the different dosage of memantine for the treatment of Critical Illness Polyneuropathy (CIP) in rats that have surgically induced sepsis, by using electromyography (EMG) signs, such as amplitude and duration of compound muscle action potentials (CMAP), distal latency, and by using levels of plasma tumor necrosis factor (TNF)-α and lipid peroxides (malondialdehyde, (MDA)). METHODS: Rats were divided into five groups and cecal ligation and puncture (CLP) procedure was performed on 24 rats. Study groups were designed as follows: Group 1: normal (control, n=6); Group 2: sham-operated (n =6); Group 3: CLP (untreated group, n = 8); Group 5: CLP and 15 mg/kg memantin (n = 8); Group 6: CLP and 30 mg/kg memantin (n = 8). EMG was performed and plasma MDA and TNF-α levels were evaluated in all groups. RESULTS: Our findings showed an increase at the plasma levels of TNF-α and MDA in cecal ligation and puncture group. Besides, we established a reduction in CMAP amplitude and prolongation of distal latency in CLP goup. Administration of 15 and 30 mg/kg Memantine significantly provided a decrease in TNF-α and MDA levels in CLP group. CMAP distal latency was reduced in all memantine-treated groups. CONCLUSION: We observed that memantine showed its antioxidant and neuroprotective effects by decreasing the plasma MDA and TNF- α levels in CIP.