The Presentation of Clinical Results of Radiolabelling of 99mtcMIBI Complex Using Ultrasound Technique for Myocardial Perfusion Scanning (MPS)

Abstract

The initial objective and opinion of this study is introducing the clinical results of the 99mTc-MIBI complex radiolabelling utilizing ultrasound method as an approach for labeling MIBI kits with 99mTc instead of applying a boiling water bath as a usual and standard method. The results provided in this research applying radio-HPLC and ITLC, indicate that radio-labeling of MIBI vial with 99mTc can be provided with high effectiveness and appropriate acceptance applying ultrasound method as a novel approach. The imaging research applying SPECT indicated that the 99mTc-MIBI complex samples that were made ready applying ultrasound irradiation approach indicate very similar biodistribution in the heart, thyroid, lung, liver, gallbladder, kidneys, stomach, GI and bladder of the volunteer patients. Non-habitual aggregation of 99mTc-MIBI samples were not observed in our approach. This research indicated that sonication approach can be proposed for providing 99mTc-MIBI radiocomplex samples. The reaction time to provide radio-complex can be considerably decreased compared to the boiling water bath approach. This main development may decrease potential risk to the patient to inhibit any delay in emergency situations like acute therapy, especially for myocardial infarction patients in clinical practice