Abstract
Resume. 1). Preparations of dried stomach substance from the cardia, fundus and pylorus parts of the pig's stomach have been tested for their therapeutic activity in pernicious anaemia. 2). In excising the material for the preparations used in the present experiments, the anatomical distribution of the different gland elements in the pig's stomach has been taken into consideration (see Meulengracht and Soeborg Ohlsen). 3). It has been shown that preparations from the pyloric gland region were highly active, while those from the fundus gland region were inactive. The question of the activity or inactivity of preparations from the cardia gland region is still an open one. 4). Castle's «intrinsic factor», which is present in normal gastric juice seems thus to be connected with (produced by) the pyloric glands (the cardia glands?). 5). The results obtained make it probable that pernicious anaemia in man is due to atrophy and inactivity chiefly of the pyloric gland organ (the cardia gland organ?), that is, to the failure of a special function which is localised there.
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