Abstract
The aim of this systematic review and meta-analysis was to analyze the available evidence on the assessment of periodontal disease in patients with von Willebrand disease (VWD). An electronic search in three databases (PubMed, Web of Science, and Scopus) was conducted by three independent reviewers to identify cross-sectional, cohort, and clinical trial studies. Studies considered eligible for this review were evaluated according to the quality and risk assessment tool proposed by the CLARITY Group at McMaster University. In order to analyze the possible correlation of VWD patients and periodontitis and their susceptibility to bleeding during the periodontal screening phase, periodontal parameters evaluated were probing pocket depth (PPD), bleeding on probing (BOP), gingival bleeding index (GBI), and periodontal inflamed surface area (PISA). After a screening of 562 articles, three articles were selected for the qualitative analysis. Within the limitation of our review, VWD patients are not more susceptible to periodontitis as compared with non-VWD patients. Nevertheless, bleeding on probing and gingival index needs to be carefully taken into consideration during periodontal screening of VWD due to the possible presence of false positives.
Highlights
Periodontal disease is included by the World Health Organization (WHO) in the category of most recurring pathologies related to oral health, next to dental cavities, microbial infections, tumors, and injuries
The various etiological components of the pathology represented by microbial load, personal defense mechanisms, existing degrees of inflammation, and background circumstances coexist and determine the complex definition of periodontal disease [3]
This systematic review was prepared according to the PRISMA guidelines [14] and the protocol details were registered in the PROSPERO database under the code CRD42021246930
Summary
Periodontal disease is included by the World Health Organization (WHO) in the category of most recurring pathologies related to oral health, next to dental cavities, microbial infections, tumors, and injuries. Up to 20% of the European population aged 35–44 suffer from advanced clinical forms of periodontitis, the percentage being significantly higher in the elderly population. Studies concluded that periodontal pathologies affect up to 50% of the entire globe population [2]. The various etiological components of the pathology represented by microbial load, personal defense mechanisms, existing degrees of inflammation, and background circumstances coexist and determine the complex definition of periodontal disease [3]. Sci. 2021, 11, 6408 existing degrees of inflammation, and background circumstances coexist and determine the complex definition of periodontal disease [3]
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