The presence of MTDNA mutations in THP1-based cybrid cells affects the efficiently of FCCP-induced mitophagy

Abstract

Background and Aims : Mitophagy is an effective way to clearance of dysfunctional mitochondria. A disturbance in the clearance of dysfunctional organelles and their accumulation may indicate that mitophagy is defective. We hypothesize that mtDNA mutations may cause defective mitophagy.