Abstract
BackgroundRecently, CD4+IL-17A+ T helper 17 (Th17) cells were identified and reported in several diseased states, including autoimmunity, infection and various peripheral nervous system tumors. However, the presence of Th17 in glia-derived tumors of the central nervous system has not been studied.Methodology/Principal FindingsIn this report, we demonstrate that mRNA expression for the Th17 cell cytokine IL-17A, as well as Th17 cells, are present in human glioma. The mRNA expression for IL-17A in glioma was recapitulated in an immunocompetent mouse model of malignant glioma. Furthermore, the presence of Th17 cells was confirmed in both human and mouse glioma. Interestingly, some Th17 cells present in mouse glioma co-expressed the Th1 and Th2 lineage markers, IFN-γ and IL-4, respectively, but predominantly co-expressed the Treg lineage marker FoxP3.ConclusionsThese data confirm the presence of Th17 cells in glia-derived CNS tumors and provide the rationale for further investigation into the role of Th17 cells in malignant glioma.
Highlights
These data confirm the presence of T helper 17 (Th17) cells in glia-derived central nervous system (CNS) tumors and provide the rationale for further investigation into the role of Th17 cells in malignant glioma
Glioma, which is a tumor that arises from a cell with glial lineage in the central nervous system (CNS), is a categorical designation for multiple types of glial tumors, including ependymomas, astrocytomas, oligodendrogliomas and glioblastoma multiforme (GBM)
We report that mRNA for the Th17 cytokine, IL-17A, is expressed in immunocompetent mice with glioma, but not in Rag12/2 immunodeficient mice with glioma
Summary
Glioma, which is a tumor that arises from a cell with glial lineage in the central nervous system (CNS), is a categorical designation for multiple types of glial tumors, including ependymomas, astrocytomas, oligodendrogliomas and glioblastoma multiforme (GBM). Our lab demonstrated that a specific subset of T helper cells, CD4+CD25+ T regulatory (Treg) cells, are increased in human GBM [2], as well as various grades of astrocytoma [3]. We demonstrated that Treg depletion in a mouse model of malignant glioma significantly increases lifespan [4]. These data suggest that T helper subsets, such as Treg, are potential targets for future therapy of GBM. The presence of Th17 in gliaderived tumors of the central nervous system has not been studied
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