Abstract
The relation of streptococcal cell products to pathogenicity of the group A streptococci has been the subject of many investigations and has led to the realization that no single extracellular or intracellular component can be equated to the virulence of these organisms. However, there is considerable evidence to establish type-specific M antigen as the most important virulence factor of group A streptococci. The literature regarding the preparation and properties of M antigen and its role as a virulence factor has recently been reviewed by Lancefield (1962). That M antigen is a major virulence factor is based largely upon indirect evidence. Strains virulent for mice and resistant to phagocytosis generally contain M antigen. Blocking M antigen with specific antibody or removing it enzymatically results in a decrease in virulence or in resistance to phagocytosis. Furthermore, mice can be protected against virulent group A streptococci with homologous anti-M serum. In the present study we investigated, by a more direct approach, the role of M protein as a virulence factor. Essentially, acid extracts of M protein were
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
