Abstract
1. 1. The possibility that blood plasma of a variety of animals contains a relatively low molecular weight fraction with positive inotropic activity similar to that found in human blood plasma was investigated. 2. 2. Five per cent cross-linked polyacrylamide gel was used to isolate the fraction with a molecular weight in the range 4,000–10,000. 3. 3. When isolated from the plasmas of lampreys, fish, toads, tortoises, lizards, monkeys, rats, rabbits, guinea-pigs, dogs and domestic fowls this fraction was found to possess positive inotropic activity (on the isolated toad ventricles) which was not blocked by the β-adrenergic blocking drug, pronethalol.
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