Abstract
Fluorescence/temperature-sensitive hydrogels, thanks to their properties in fluorescence and temperature sensitivity, have shown a promising outlook in the fields of drug delivery, cell imaging, etc., and thus become the focus of present research. This paper reports the preparation of green-fluorescence/temperature-sensitive hydrogels through one-step radical polymerization with green fluorescence-emissioned carbon dots as fluorescence probes and N-isopropylacrylamide as a monomer. UV-vis spectra, fluorescence spectra, and fluorescence microscope imaging have been used to characterize the prepared hydrogel, and to study their optical and temperature-sensitive properties. It was discovered that the emission of prepared hydrogel is excitation wavelength-dependent, pH responding, and excellent temperature-sensitive, as well as having good biocompatibility. The prepared hydrogel can also be applied as fluorescence ink in the fields of anti-counterfeit identification and appraisal.
Highlights
Thanks to its excellent biocompatibility [1,2], optical stability [1], low toxicity [1,2], and temperature-sensitivity [1,2], fluorescence/temperature-sensitive hydrogels attract increasing research interest as a new multi-functional smart material, exhibiting promising outlook in the fields [1,3,4,5]of drug delivery, chemical sensor, and biological imaging
N-isopropylacrylamide (NIPAM), N,N’-methylenebisacrylamide (BIS), and ethylene imine polymer (PEI1800 ) were obtained from Aladdin Chemistry Co., Ltd. (Shanghai, China); acrylic acid (AAc), potassium persulphate (KPS), L-ascorbic acid (AA), citric acid monohydrate (CA), and dimethyl sulfoxide (DMSO) were purchased from Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China); cyclohexane was obtained from Tianjin Bodi Chemical Co., Ltd. (Tianjin, China); and acetone was purchased from Tianjin Fuyu Fine Chemical Co., Ltd. (Tianjin, China)
This paper reports the synthesis of Carbon dots (CDs)/PNIPAM hydrogel with excellent fluorescence property and temperature-sensitivity
Summary
Thanks to its excellent biocompatibility [1,2], optical stability [1], low toxicity [1,2], and temperature-sensitivity [1,2], fluorescence/temperature-sensitive hydrogels attract increasing research interest as a new multi-functional smart material, exhibiting promising outlook in the fields [1,3,4,5]. Polymers 2019, 11, 1171 poly(N-isopropylacrylamide) at room temperature and in a certain pH environment Liras and his team [14] used methacrylic acid group-modified CdSe QDs and poly(diethylene glycol methyl ether methacrylate) as raw materials and prepared temperature sensitive smart hydrogel through free radical polymerization. These types of synthesis methods are simple in operation, and the prepared hydrogel exhibits reversible temperature-dependent fluorescence. CDs into temperature-sensitive poly(N-isopropyl acrylamide) (PNIPAM) hydrogels through free radical polymerization to get fluorescent/temperature-sensitive complex hydrogels Li and his team [3] used blue-emissioned CDs to copolymerize with NIPAM to get fluorescent/temperature-sensitive hydrogel, and applied it into cell imaging. This research would provide new material for a wide range of fields like temperature-sensitive sensors, drug carrier system, fluorescent labeling, fluorescent coding, and fluorescent ink
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