Abstract
Objective To study and optimize the preparation process and abserve the related properties of electret fluorouracil gel patch. Methods the adhesives and moistening agents were screened by preliminary experiment. The optimal matrix proportion in the blank gel patch was obtained with orthogonal design. The charge storage stability of the patch was studied by compensation method. The transdermal behaviors of the patch were evaluated by modified diffusion cell method and HPLC. Results The optimal matrix proportions of PAAS:gelatin:PVA:Kaolin:CMC-Na:moistening agents were 0.2:0.7:0.5:0.7:0.2:12.The patch had a good charge storage stability. All the electrets and 3% azone could enhance the cumulative penetration amount of drug and they had synergistic enhancing effect. Conclusion The qualified electret fluorouracil gel patch was prepared under the optimal process, which had no skin irritation and the behavior of transdermal delivery was better than that of the traditional gel patch.
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