Abstract
This study aimed to research the preparation and content determination of capsaicin-chitosan microspheres (CCMS) enteric coated tablets. The core tablets were prepared with the method of wet granulation. Nine formulae were designed to determine the optimal formula of the core tablet. Eudragit L100 was used to prepare the CCMS enteric-coated tablets. The effect of enteric coated formulation variables such as content of talc (10%, 25% and 40%), plasticisers (TEC and DBS), dosage of plasticiser (10%, 20% and 30%) and coating weight (2%, 3% and 5%) were evaluated for drug release characteristics. The in vitro release was studied using 0.1 N HCl and pH 6.8 phosphate buffer. Enteric coated tablets without ruptures or swelling behaviour over 2 h in 0.1 N HCl indicated that these tablets showed acid resistance. The accumulated release rate in phosphate buffer (pH 6.8) revealed that the prepared tablets were able to sustain drug release into the intestine and a first-order release was obtained for capsaicin. This research is the first report of the preparation and content determination of CCMS enteric coated tablets. The sustained release behavior of enteric coated formulations in pH 6.8 phosphate buffer demonstrated that it would be a potential drug delivery platform for sustained delivery of gastric irritant drugs.
Highlights
Obesity, the result of energy intake in excess of energy expenditure, is gradually spreading to low- and middle-income countries, such as China, as a result of novel dietary habits [1,2]
The results of content determination experiments on three batches of capsaicin-chitosan microspheres (CCMS) enteric coated tablets are shown in the Table 4
The results revealed that each CCMS enteric coated tablet contained, on average, 5.44 mg CAP, and preparation of enteric coated tablets was mature and stable
Summary
The result of energy intake in excess of energy expenditure, is gradually spreading to low- and middle-income countries, such as China, as a result of novel dietary habits [1,2]. Nutrition Health Survey (CHNS) reported that, as of 2009, the proportion of obese men has reached. 11.4%, the female has reached 10.1%, and the proportion of male abdominal obesity was 27.8%, and the female was 45.9% [8]. Capsaicin (CAP) is a natural product, extracted from chilli, which can reduce the absorption of fat in the intestine and accelerate the rate of metabolism of fat, promoting the burning of fat in the body. These properties have significant effects for weight reduction [21,22,23]
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