Abstract
The preparation of a physiologically potent extract of the adrenal cortex, suitable for intravenous administration in laboratory and clinical experimentation, was placed upon a firm footing in 1929 (1) when conclusive evidence was presented by the authors to show that the cortical hormone, essential to the maintenance of life, can be readily extracted from beef adrenal glands with lipid solvents. It was also observed at that time that the solubility of adrenalin in the common lipid solvents was markedly influenced by the presence of lipid materials, particularly phospholipid. Consequently the crude lipid fractions which contained the cortical hormone also contained variable amounts of adrenalin. In order to obtain a relatively pure preparation of cortical hormone it was necessary therefore to fractionate with two objectives in view: (1) the separation of the cortical hormone from lipid material, and (2) the separation from adrenalin. A flow sheet by means of which both these objectives have been attained ...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
