Abstract
Iron-chelating peptides have been widely considered as one of the best iron supplements to alleviate the iron deficiency. In this study, a novel oat peptides–ferrous (OP-Fe2+) chelate was prepared from antioxidant oat peptides obtained in the laboratory of the authors. The optimal preparation condition was obtained through the single-factor and response surface methodology, and the chelating rate could reach up to 62.6%. After chelation, the OP-Fe2+ chelate exhibited a significantly higher 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity than oat peptides. It was discovered that the hemoglobin concentration and the number of red blood cell levels in OP-Fe2+-treated iron-deficient anemic (IDA) rats were significantly higher than untreated IDA rats. The OP-Fe2+ chelate could also improve the hypertrophy of the spleen, serum iron (SI), total iron and binding capacity, and serum ferritin levels in the IDA rats. In addition, the OP-Fe2+ treatment significantly increased the antioxidant activities of super oxidase and glutathione in the liver homogenate of the IDA rats. Therefore, the OP-Fe2+ chelate is an effective type of iron supplement for IDA rats, which could be a promising source with anti-anemia and antioxidant activity.
Highlights
Iron, a kind of essential trace element for humans and animals, participates in multiple biological processes, such as protein and DNA synthesis [1]
Statistical Analysis and Model Fitting The chelating rate of oat peptides (OPs)-FeCl2 was optimized by RSM using the Box–Behnken design method
The results showed that pH value had a significant effect on chelation rate, while the other factors had no significant effect
Summary
A kind of essential trace element for humans and animals, participates in multiple biological processes, such as protein and DNA synthesis [1]. Iron works as a vital part of cytochrome, hemoglobin, and enzymes, and plays an important role in transporting and storing oxygen for breathing and metabolism [2]. Iron deficiency may cause anemia, with common symptoms, such as fatigue, dizziness, and irritability. Iron deficiency anemia has been regarded as a global problem that troubles one third of the global population, infants, pregnant women, and the elderly [3]. The most common manifestations are pregnancy accidents as well as developmental delay and cognitive impairment in young children. Iron deficiency could result in a series of dysfunctions, such as chronic fatigue and weakened immune function in adults [5]
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