Abstract
Recently, the functionalization of organic molecules with fluorine substituents has grown rapidly due to its applications in such fields as medicine, agriculture or materials sciences. The aim of this article is to review the importance of 1,1-difluorocyclopropane derivatives in synthesis. It will examine the role of the fluorine substituents in both ring-forming and ring-opening reactions, as well as methods for obtaining difluorocyclopropanes as single enantiomers. Several examples are provided to highlight the biological importance of this class of compounds.
Highlights
The chemistry of cyclopropane derivatives is one of the most intensively developing fields of organic chemistry
In the past decade there have been made many investigations to develop new chemo, regio- and stereoselective methods for the synthesis and transformations of cyclopropane derivatives. These investigations gained a significant interest, because cyclopropane and cyclopropene fragments are present in the structures of many biologically active substances, such as antibiotics, anticancer, and antimycotic preparations, controllers of plant growth and fruit ripening, and insecticides
Especially the fluoro derivatives, form an important class of organic compounds, which have the ability to participate in synthetically useful reactions due to the presence of both, ring strain and of the gem-dihalomethylene fragment. They are of interest for the direct application as biologically active substances and functional materials and as precursors to other fluorine-containing compounds [1,2]
Summary
The chemistry of cyclopropane derivatives is one of the most intensively developing fields of organic chemistry. Especially the fluoro derivatives, form an important class of organic compounds, which have the ability to participate in synthetically useful reactions due to the presence of both, ring strain and of the gem-dihalomethylene fragment. They are of interest for the direct application as biologically active substances and functional materials and as precursors to other fluorine-containing compounds [1,2]. Incorporating a fluorine group into natural compounds has been widely accepted as a powerful tool
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