Abstract
The high concentration of Zn2+ ion locally released due to the degradation of zinc (Zn) implants causes cytotoxicity, hindering the clinical application of Zn. Herein, bioactive Sr2+ doped zinc phosphate (Sr-P) coatings were prepared by a feasible chemical conversion method to improve the biocompatibility of biomedical Zn. The reaction thermodynamics were regulated by different reaction parameters to further regulate the chemical composition and surface morphology, and in vitro release of metal ions of the Sr-P coatings. The Sr-P coating with the most obvious inhibition effect on Zn2+ ion release was selected for the in vitro cell assays. Sr-P coating presents a promising surface modification strategy to improve biocompatibility for biodegradable Zn.
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