Abstract
In ADHD, pyramidal neurons in the prefrontal cortex are hypothetically out of tune, causing either deficient signals, excessive noise, or both. Specific malfunctioning brain areas within the prefrontal cortex theoretically mediate the various symptoms of ADHD. Inefficient information processing in related areas of prefrontal cortex may also cause the specific symptoms of the common comorbidities of ADHD, such as bipolar disorder, anxiety disorders, conduct disorder, and oppositional defiant disorder.
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