Abstract
Aim: This study aims to evaluate the association between prognostic nutritional index (PNI) and contrast-induced nephropathy (CIN). Material and methods: A total of 251 patients who were at high risk for contrast nephropathy were included in the study. The patients were grouped according to their PNI score (PNI score <45 or PNI score ≥45). CIN was defined as a 25% relative increase, or 0.5 mg/dL absolute increase in serum creatinine level above baseline within 72 hours of contrast exposure, in the absence of an alternative explanation. Results: Two groups were assigned according to the PNI score. The first group consists of 111 patients (PNI<45) and the second group has 140 patients (PNI≥45). CIN developed in 162 (%64.8) patients. C-reactive protein was higher in the low-PNI group. Also, the patients with the low-PNI group had lower ejection fraction, lower serum albumin levels, and lower hemoglobin levels. CIN, postprocedure renal replacement therapy requirement and in-hospital mortality were higher in the low PNI group. Multivariable logistic regression analysis revealed that advanced age (p=0.012, [OR] = 1.044 [1.009-1.079]), low baseline GFR (p=0.033, [OR]= 1.022 [1.002-1.043]), high amount of contrast media (p=0.022, [OR]= 1.017 [1.002-1.031]), and low PNI score (p=0.033 , [OR]= 2.069 [1.060-4.039]) were independent predictors of CIN. Conclusion: Our study demonstrated that the PNI score was an independent risk factor for the development of CIN.
Highlights
Contrast-induced nephropathy (CIN) is a potentially benign form of acute kidney injury (AKI) that occurs following contrast media administration
The aim of this study is to explore the predictive effect of prognostic nutritional index (PNI) on CIN in patients that underwent coronary angiography (CAG) or percutaneous coronary intervention (PCI)
The values of C-reactive protein (CRP) were higher in the low-PNI group
Summary
Contrast-induced nephropathy (CIN) is a potentially benign form of acute kidney injury (AKI) that occurs following contrast media administration. CIN is a common cause of AKI in hospitalized patients, and the incidence of it varies from 3% to 30% in different studies due to the contrast volume, accompanying risk factors, and route of administration [1]. It is generally reversible, CIN development is associated with increased prolonged hospitalization and mortality [2]. Once it occurs, there are no spesific treatment options for CIN yet [3]. It is very important to identify the population at risk and take measures to prevent AKI progression [3]
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