Abstract
Abstract Objectives Left ventricular thrombus is regarded as one of the main myocardial infarction complications. Knowing the left ventricular thrombus symptoms prevents serious complications that may occur. This study aims to reveal any association between SCUBE-1 and left ventricular thrombus, thought to be involved in platelet aggregation and adhesion. Methods The study included 80 patients diagnosed with heart failure following acute myocardial infarction, applying for the cardiology outpatient clinic for third-month follow-up. The patients were included in two groups to see if the left ventricular thrombus was present. Thus, 22 patients were found to have left ventricular thrombus. The two groups were compared based on clinical laboratory and echocardiographic parameters. Results It was found that the patients with left ventricular thrombus had significantly higher Serum SCUBE-1 levels (p<0.001). The optimal cutoff point of SCUBE-1 levels for predicting the LVT was >35.1 ms, with the specificity of 86% and sensitivity of 68.4% (AUC=0.815; 95% CI, 0.699–0.931; p<0.0001). SCUBE -1 level (OR=1.090, 95% CI: 1.034–1.150, p<0.001) in the multiple logistic regression model continue to significantly predict LVT after adjusting for the confounding variables, as statistically significant in the univariate analysis of the variables which correlated with the SCUBE-1 levels. Conclusions SCUBE-1 level was determined to independently predict the left ventricular thrombus after a previous anterior myocardial infarction.
Highlights
Left ventricular thrombus (LVT) is one of the myocardial infarction (MI) main complications [1]
This study aims to reveal any association between SCUBE-1 and left ventricular thrombus, thought to be involved in platelet aggregation and adhesion
This study aimed to investigate the relationship between LVT and serum SCUBE-1 levels in patients suffering from heart failure after MI
Summary
Left ventricular thrombus (LVT) is one of the myocardial infarction (MI) main complications [1]. A protein with a signal peptide at the amino-terminus is encoded by this new mammalian gene before one CUB (complementC1r/C1s) domain at the carboxyl terminus and several EGF (epidermal growth factor)-like repeats. Such a family of genes was called SCUBE-1 for proteins containing signal-peptide-CUB-EGFlike domain [9,10,11]. SCUBE-1 (protein 1 containing signal peptide-cub-EGF-like domain) has been identified in platelet-rich thrombus and atherosclerotic lesions. The recombinant fragments of SCUBE-1 were found to increase aggregation and adhesion of platelets [12, 13]
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