The predictive value of serum presepsin (sCD14-ST) for myocardial depression in septic patients

Abstract

Objective To evaluate the predictive value of serum presepsin (sCD14-ST) for septic myocardial depression (SMD) in patients with severe sepsis or septic shock. Methods This was a prospective cohort study. A total of 84 patients with severe sepsis or septic shock were monitored by pulse indicator continuous cardiac output (PiCCO) system and divided into myocardial depression group (cardiac function index [CFI] <4.1 L/min, n=37) and non-myocardial depression group (CFI≥4.1 L/min, n=47) according to cardiac function index (CFI). Left ventricular ejection fraction (LVEF) was measured by doppler echocardiography at admission. The patients were divided into survival group (n=40) and non-survival group (n=44) based on 28-day mortality. Serum sCD14-ST, B-type natriuretic peptide(BNP), tumor necrosis factor-α(TNF-α), cardiac troponin Ⅰ (cTnⅠ) levels and hemodynamic parameters were observed dynamically at day 1, 3, 5 after admission. Quantitative data with normal distribution were analyzed using t-test and abnormal distribution data were analyzed using Mann-Whitney U test. Categorical data were analyzed using χ2 test. Results The serum levels of cardiac index (CI), global ejection fraction (GEF) and left ventricular contractility index (dPmax) in myocardial depression group were all significantly lower than those in non-depression group at day 1 after admission (all P 0.05). There were 24 cases died in myocardial depression group. The mortality of myocardial depression group was significantly higher than that of non-depression group (64.9% vs 42.6%, χ2= 4.132, P = 0.042). The serum levels of sCD14-ST at day 1 and day 3 in myocardial depression group were significantly higher than those in non-myocardial depression group (both P<0.01). sCD14-ST levels in both groups showed downtrend. The serum level of sCD14-ST in non-survival group was significantly higher than that in survival group (P<0.01). Conclusions Myocardial depression is common in patients with severe sepsis and septic shock. High serum level of sCD14-ST is correlated with myocardial depression to some extent, but not an independent predictor. The combination of sCD4-ST, BNP and TNF-α can improve the predictive value for myocardial depression. Key words: Sepsis; sCD14-ST; Tumor necrosis factor-alpha; BNP