The predictive value of serum advanced fibrinogen and uric acid for acute coronary event risk

Abstract

To study the serum advanced fibrinogen (FIB) and uric acid (UA) in predicting acute coronary events risk. 264 patients hospitalized with the suspected diagnosis of coronary heart disease (CHD) were divided into 2 groups according to the results of coronary arteriography: acute coronary event group (n = 195, 141 males and 54 females, aged 62 +/- 12, with laboratory and electrocardiogram proven acute myocardial infarction or unstable angina pectoris and obvious stricture of main coronary artery > 75%) and control group (n = 69, 31 males and 38 females, aged 65 +/- 9, without acute coronary event and with normal coronary artery or stricture of branches of coronary artery less than 50%). A week before the coronary arteriography fast peripheral venous blood samples were collected. The blood sugar, blood-lipid, FIB, and UA were determined. The FIB level of the acute coronary event group was 4.09 g/L +/- 1.36 g/L, significantly higher than that of the control group (3.52 g/L +/- 1.37 g/L, P < 0.05). The UA level of the acute coronary event group was 320 micromol/L +/- 91 micromol/L, not significantly different from that of the control group (302 micromol/L +/- 104 micromol/L, P > 0.05). Excluding the influence of age, sex, blood pressure, blood sugar, etc. multivariate analysis showed that FIB was a significant variable associated with acute coronary events, but UA, not entering the regression equation, was not an independent risk factor. When FIB and UA were both at high levels, acute coronary events risk was much higher than when any single index was at a high level. High FIB and UA jointly accelerate the development of atherosclerosis. It may be important to use the index of FIB associated with UA to predict acute coronary risk.