Abstract
BackgroundDiagnosis of endometrial receptivity is still unclear and conflicting. Despite advances in embryo development during assisted reproductive technologies (ART) cycles, the intricate process of implantation is still matter for debate and research.Materials and methodsProspective case control of 169 subjects during ovarian controlled stimulation for ART. Endometrial receptivity assessment to predict clinical pregnancy with serial continuous biochemical (serum estradiol) and biophysical (endometrial volume and adjusted endometrial volume) parameters were used. Both parameters were compared between negative and positive outcome in terms of clinical pregnancy.ResultsNo statistical difference was noted between the two groups in terms of demographics and ART procedures and scores. Serum estradiol was significantly higher in the positive group from day 8 after ovarian controlled stimulation. Endometrial volume and adjusted endometrial volume were significantly higher in the positive group as soon as day 6 of ovarian controlled stimulation.ConclusionsContinuous serum estradiol and 3D endometrial volume and adjusted endometrial volumes may reflect endometrial changes during ART procedures and provide a useful real time tool for clinicians in predicting endometrial receptivity.
Highlights
Since the introduction of assisted conception, many techniques have been developed to improve ovarian stimulation, oocyte retrieval, and embryo culture, but despite this, more than 70% of apparently normalSilva Martins et al BMC Pregnancy and Childbirth (2021) 21:184 unclear, poorly understood and matter for many discussion and study.The impact of serum estradiol levels in assisted reproductive techniques (ART), has been debated for over 25 years with conflicting results about the effect of supraphysiological levels of estradiol during controlled ovarian stimulation
Demographics characteristics and assisted reproductive technologies (ART) parameters of the 169 subjects are shown in Table 1 and no statistical difference between the two set groups in terms of demographics and ART parameters was met, especially in terms of overall median number of harvested oocytes per cycle
The underlying mechanism that results in failure of implantation of a good quality embryo on a supposed receptive endometrium is still unclear
Summary
Introduction Since the introduction of assisted conception, many techniques have been developed to improve ovarian stimulation, oocyte retrieval, and embryo culture, but despite this, more than 70% of apparently normal. The impact of serum estradiol levels in assisted reproductive techniques (ART), has been debated for over 25 years with conflicting results about the effect of supraphysiological levels of estradiol during controlled ovarian stimulation. High levels of estradiol and its influence on embryonic implantation, and embryonic development is still controversial and unclear. Many has been published regarding the deleterious effects of supraphysiological levels of estradiol on ovarian stimulation for ART procedures. Questions have been raised concerning high levels of estradiol and the impairment caused by it on endometrial receptivity. Despite advances in embryo development during assisted reproductive technologies (ART) cycles, the intricate process of implantation is still matter for debate and research
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