The predictive value of hematological inflammatory markers for acute kidney injury and mortality in adults with hemophagocytic Lymphohistiocytosis: A retrospective analysis of 585 patients.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare immunological hyperactivation-related disease with a high mortality rate. The purpose of this study was to examine the relationship between complete blood count parameters and the occurrence of acute kidney injury (AKI) and mortality in patients with HLH. We included 585 adult patients with HLH. Logistic regression models for AKI and 28-day mortality were developed. Multivariate logistic regression models revealed that hemoglobin (HB)≤7.3g/dl (adjusted OR, 1.651; 95% CI, 1.044-2.612), hemoglobin-to-red blood cell distribution width ratio (HRR)<0.49 (adjusted OR, 1.692), neutrophil-to-lymphocyte ratio (NLR)≥3.15 (adjusted OR, 1.697), and neutrophil-to-lymphocyte-platelet ratio (NLPR)≥11.0 (adjusted OR, 1.608) were independent risk factors for the development of AKI. Moreover, lower platelet levels (31×109/L<platelets<84×109/L, adjusted OR, 2.133; platelets≤31×109/L, adjusted OR, 3.545) and higher red blood cell distribution width-to-platelet ratio (RPR) levels (0.20<RPR<0.54, adjusted OR, 2.595; RPR≥0.54, adjusted OR, 4.307), lymphocytes≤0.34×109/L (adjusted OR, 1.793), NLPR≥11.0 (adjusted OR, 2.898), and the aggregate index of systemic inflammation (AISI)≤7 (adjusted OR,1.778) were also independent risk factors for 28-day mortality. Furthermore, patients with AKI had a worse prognosis than those without AKI (P<0.05). In patients with HLH, hematological parameters are of great value for the early identification of patients at high risk of AKI and 28-day mortality.