Abstract
Abstract
 Background: Abnormal uterine bleeding (AUB) is one of the most common complains in women of any age seeking gynecologic health care and needs early diagnosis and proper management due to its impacts on the quality of life. This study was conducted to investigate the cut-off value of endometrial thickness (ET) by trans-vaginal ultra-sonography (TVUS) and evaluate its accuracy in the diagnosis of the endometrial abnormalities in premenopausal women with AUB.
 Materials and Methods: In this descriptive  study, 64 married women between 35-50 years old were evaluated due to AUB during 2011-2012; TVUS and fractional curettage were done. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of the ET were calculated in different cut-off values.
 Results: The pathological evaluations of the biopsies were normal in 37 (57.8%) patients and were abnormal in 27 (42.2%) patients, 19 endometrial polyps, 6 hyperplastic lesions and 2 endometrial cancers. ET=4 mm had 100% sensitivity, 100% NPV, 10% specificity and 28% PPV in the detection of endometrial abnormalities. ET<10 mm had a proper sensitivity (67%-100%) and NPV (78.6%-100%) but specificity was low (%10-%44). ET=10 mm with sensitivity=63%, specificity=60%, NPV=65.8% and PPV=48.2% was introduced as the cut-off point with the best area under curve (LR+=2.22 LR- =0.77).
 Conclusion: Although an ET<10 mm was less likely to be associated with an endometrial abnormality, the low PPV of ET and low area under ROC curve shows sonography has high false positivity in premenopausal women. ET≤4 mm was more reliable and could reduce unnecessary biopsies.
Highlights
Abnormal vaginal bleeding (AUB) is one of the most common presenting gynecologic complaints in women seeking gynecologic health care regardless of age
Endometrial Thickness and Abnormal Uterine Bleeding in Premenopausal Women curs in women of late reproductive age due to higher possibility of malignancies
In contrast with postmenopausal women, the utility of trans-vaginal ultra-sonography (TVUS) for excluding endometrial abnormalities in premenopausal women has not been established [6,7].Ultrasound cannot discriminate between proliferative endometrium, benign endometrial disease, and cancers, all of which cause an increase in endometrial thickness
Summary
Abnormal vaginal bleeding (AUB) is one of the most common presenting gynecologic complaints in women seeking gynecologic health care regardless of age. Endometrial Thickness and Abnormal Uterine Bleeding in Premenopausal Women curs in women of late reproductive age due to higher possibility of malignancies. Considering the lack of data about accuracy of TVUS in diagnosis of the endometrial pathologies in premenopausal women, this study was conducted to investigate a cutoff point of ET in women above 35 years old with AUB for the first time in Iran. Abnormal uterine bleeding (AUB) is one of the most common complains in women of any age seeking gynecologic health care and needs early diagnosis and proper management due to its impacts on the quality of life. This study was conducted to investigate the cut-off value of endometrial thickness (ET) by trans-vaginal ultra-sonography (TVUS) and evaluate its accuracy in the diagnosis of the endometrial abnormalities in premenopausal women with AUB. ET≤4 mm was more reliable and could reduce unnecessary biopsies. [GMJ. 2013;2(4):141-5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
