Abstract

Purpose: Studies report that plasma NT-proBNP and BNP have prognostic value for mortality in the general population even in the absence of heart failure (HF). It is unclear if NT-proBNP and BNP retain prognostic value in individuals who are free of traditional cardiovascular risk factors (CV RFs) or structural cardiac abnormalities (SCA). Methods: We identified a community-based cohort of 2,006 subjects in Olmsted Co, Minnesota. We excluded those with HF. The remaining 1,991 subjects underwent echocardiography, NT-proBNP (Roche) and BNP (Biosite and Shionogi) measurement, and identification of age/gender specific 80th percentile NT-proBNP and BNP levels.

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