The Predictive Value of Basic Lung Function and Dosimetric Parameters to Acute Radiation Pneumonitis (ARP) during the Treatment of Concurrent Chemoradiotherapy

Abstract

Results: (1) For patients with esophageal carcinoma, 34.1% developed RP (9 grade 1, 3 grade 2 and 2 grade 3). For patients with NSCLC, 95.7% developed RP (9 grade 1, 8 grade 2 and 5 grade 3). There was no significant difference of FVC (forced vital capacity) and FEV1.0 (forced expiratory volume in 1s) between esophageal carcinoma and NSCLC patients, but the DLCO (diffusion capacity of carbon monoxide) of NSCLC was significantly lower than that of esophageal carcinoma. (2) The volume of GTV, FEV1.0, DLCO and all dosimetric parameters (MLD, NTCP, and V5-30) could predict RP according to univariate analysis. For patients whose FVC\80% and $80%, DLCO #80% and .80%, FEV1.0\70% and $70% before irradiation, the incidence of $2 grade RP was 38.1%vs23.3%, 35.1%vs18.5% and 66.7%vs21.8%, respectively. For patients whose chemotherapy cycles #2 and.2, the incidence of severe RP was 14.3% and 38.9%, respectively.(3)The volume of GTV, cycles of chemotherapy, MLD and V20 were found independently associated with RP according to multivariate analysis.