Abstract
Objective:To detect the clinicopathological factors associated with lymph node metastases in early gastric cancer.Methods:We retrospectively evaluated the distribution of metastatic nodes in 198 patients with early gastric cancer treated in our hospital between May 2008 and January 2015, the clinicopathological factors including age, gender, tumor location, tumor size, macroscopic type, depth of invasion, histological type and venous invasion were studied, and the relationship between various parameters and lymph node metastases was analyzed.Results:In this study, one hundred and ninety-eight patients with early gastric cancer were included, and lymph node metastasis was detected in 28 patients. Univariate analysis revealed a close relationship between tumor size, depth of invasion, histological type, venous invasion, local ulceration and lymph node metastases. Multivariate analysis revealed that the five factors were independent risk factors for lymph node metastases.Conclusion:The clinicopathological parameters including tumor size, depth of invasion, local ulceration, histological type and venous invasion are closely correlated with lymph node metastases, should be paid high attention in early gastric cancer patients.
Highlights
Gastric cancer, with a high prevalence and the second most common cause of cancer-related death, remains an important health problem in the world.[1]
Lymph node metastasis was detected in 28 patients, the lymph node metastases rate was 14.1%
The findings revealed a close relationship between tumor size, depth of invasion, histological type, venous invasion, local ulceration and lymph node metastases
Summary
With a high prevalence and the second most common cause of cancer-related death, remains an important health problem in the world.[1]. (EGC) is defined as a lesion confined to the mucosa or the submucosa, irrespective of the presence of regional lymph node metastases.[2] Compared to advanced gastric cancer, EGC presents with a better surgical and clinical outcomes. Clinical studies have showed that the prognosis of EGC with lymph node metastasis is different from those without. Lymph node metastasis (LM) is an important prognostic risk factor for EGC,[4,5] following which surgeons can determine the surgical strategies. The objectives of our study was to detect the clinicopathological factors associated with lymph node metastases in EGC and help surgeons choose an optimal surgical treatment strategies
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