Abstract
Background The incidence of diabetes mellitus (DM) was increasing in recent years, and it is important to screen those nondiabetic populations through health examination to detect the potential risk factors for DM. We aimed to find the predictive effect of health examination on DM. Methods We used the public database from Rich Healthcare Group of China to evaluate the potential predictive effect of health examination in the onset of DM. The colinear regression was used for estimating the relationship between the dynamics of the health examination index and the incident year of DM. The time-dependent ROC was used to calculate the best cutoff in predicting DM in the follow-up year. The Kaplan-Meier method and Cox regression were used to evaluate the HR of related health examination. Results A total of 211,833 participant medical records were included in our study, with 4,172 participants diagnosing as DM in the following years (among 2-7 years). All the initial health examination was significantly different in participants' final diagnosing as DM to those without DM. We found a negative correlation between the incidence of years of DM and the average initial FPG (r = −0.1862, P < 0.001). Moreover, the initial FPG had a strong predictive effect in predicting the future incidence of DM (AUC = 0.961), and the cutoff was 5.21 mmol/L. Participants with a higher initial FPG (>5.21 mmol/L) had a 2.73-fold chance to develop as DM in follow-up (95%CI = 2.65–2.81, P < 0.001). Conclusion Initial FPG had a good predictive effect for detecting DM. The FPG should be controlled less than 5.21 mmol/L.
Highlights
Diabetes mellitus (DM) is caused by various pathogenic factors such as genetic factors, immune dysfunction, microbial infections and their toxins, free radical toxins, and mental factors, leading to hypofunction of pancreatic islets and insulin resistance, which could result in a series of metabolic disorder syndromes, such as electrolytes, and electrolytes are clinically characterized by high blood glucose [1]
Despite the significance shown in statistics, the difference of high-density lipoprotein (HDL), low-density lipoprotein (LDL), blood urea nitrogen (BUN), and clearance rate (CCR) between the two groups was not shown. 71.87% of the patients were male, and 4.1% of the diabetic patients had a family history
In terms of fasting plasma glucose (FPG), we found that the incidence rate of diabetes mellitus (DM) was 0.21% in 3 years, 0.67% in 4 years, and 2% in 5 years, if initial FPG was less than 5.21 mmol/L, compared to 3.88%, 10.22%, and 24.35% if FPG was larger than 5.21 mmol/L (Figure 3)
Summary
Diabetes mellitus (DM) is caused by various pathogenic factors such as genetic factors, immune dysfunction, microbial infections and their toxins, free radical toxins, and mental factors, leading to hypofunction of pancreatic islets and insulin resistance, which could result in a series of metabolic disorder syndromes, such as electrolytes, and electrolytes are clinically characterized by high blood glucose [1]. The proportion of type 2 DM is about 95%, which is more common in middle-aged and elderly people after the age of 30 [2] In those type 2 DM patients, the secretion of insulin is not low or even higher than the healthy population and the main cause is that the body is not sensitive to insulin, that is, insulin resistance [3]. The incidence of diabetes mellitus (DM) was increasing in recent years, and it is important to screen those nondiabetic populations through health examination to detect the potential risk factors for DM. The initial FPG had a strong predictive effect in predicting the future incidence of DM (AUC = 0:961), and the cutoff was 5.21 mmol/L. The FPG should be controlled less than 5.21 mmol/L
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
