Abstract
Liver cancer is a devastating disease for humans with poor prognosis. Although the survival rate of patients with liver cancer has improved in the past decades, the recurrence and metastasis of liver cancer are still obstacles for us. Inositol polyphosphate-5-phosphatase K (INPP5K) belongs to the family of phosphoinositide 5-phosphatases (PI 5-phosphatases), which have been reported to be associated with cell migration, polarity, adhesion, and cell invasion, especially in cancers. However, there have been few studies on the correlation of INPP5K and liver cancer. In this study, we explored the prognostic significance of INPP5K in liver cancer through bioinformatics analysis of data collected from The Cancer Genome Atlas (TCGA) database. Chi-square and Fisher exact tests were used to evaluate the relationship between INPP5K expression and clinical characteristics. Our results showed that low INPP5K expression was correlated with poor outcomes in liver cancer patients. Univariate and multivariate Cox analyses demonstrated that low INPP5K mRNA expression played a significant role in shortening overall survival (OS) and relapse-free survival (RFS), which might serve as the useful biomarker and prognostic factor for liver cancer. In conclusion, low INPP5K mRNA expression is an independent risk factor for poor prognosis in liver cancer.
Highlights
Hepatocellular carcinoma (HCC) is a devastating illness for humans, which has a poor prognosis with a relatively low 5-year survival rate [1]
To evaluate the diagnostic value of Inositol polyphosphate-5phosphatase K (INPP5K) in liver cancer patients, Kaplan-Meier survival curve with the log-rank test was executed, which indicated that low INPP5K expression was associated with poor overall survival (P = 0:0071; Figure 3)
The genetic biomarkers correlated with the prognosis of liver cancer should be more widely validated in clinical trials. This is the first study that suggested the relationship between INPP5K and clinical characteristics in liver cancer patients by mining The Cancer Genome Atlas (TCGA) database so far, which indicated that low INPP5K mRNA expression may serve as an independent prognostic factor for poor survival in liver cancer
Summary
Hepatocellular carcinoma (HCC) is a devastating illness for humans, which has a poor prognosis with a relatively low 5-year survival rate [1]. Despite therapies for patients with HCC are improving the recurrence and metastasis of liver cancer are still unsurmountable obstacles for us. INPP5K belongs to the family of PI 5- phosphatase, which catalyze the dephosphorylation of the phosphate of the inositol ring on position 5 [2, 3]. It is known as skeletal muscle and kidney-enriched inositol phosphatase (SKIP) [4]. The prognostic significance of INPP5K expression in liver cancer has not been reported yet. We intend to assess the independent prognostic value of INPP5K expression for overall survival of liver cancer patients. Our results indicated that INPP5K might be a biomarker for the diagnosis and prognosis of liver cancer
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