Abstract
Objective: Pre-, pro- and postbiotics are becoming more prevalent as ingredients in cosmetic and personal care products. A novel triple biotic technology has been developed and investigated for its impact on skin flora and skin barrier properties. Methods: Growth inhibition/promotion assay was performed to determine the effect on skin bacteria growth, using Escherichia coli, Corynebacterium striatum, Staphylococcus aureus, and Staphylococcus epidermidis. A skin penetration assay and skin barrier biomarker measurements were performed using an ex vivo human skin explant model. The triple-biotic complex of inulin, 2-butyloctanol, and a biomimic blend of postbiotics was tested individually as well as part of cosmetic formulations. Results: The triple-biotic technology, either as individual components or in a cosmetic formulation, inhibited the growth of undesirable bacteria, in most cases. On the other hand, the growth of desirable bacteria was either promoted or maintained. The cosmetic formulations with the triple-biotic technology demonstrated an enhanced skin barrier and an increase in skin barrier biomarkers. Conclusion: A novel triple-biotic technology has been developed and shown to deliver a strong prebiotic effect with demonstrable benefits on bacterial growth, skin barrier properties, and the production of skin barrier biomarkers. This study indicates that triple-biotic technology can be used as a desirable prebiotic ingredient in personal care products to provide skin health benefits.
Highlights
The nature of skincare and the cosmetic/personal care industry is rapidly changing with respect to the inclusion of new and novel constituents
In comparison to the Placebo Body Wash, the Test Body Wash with the triple biotic technology demonstrated a prebiotic effect by inhibiting the growth of C. striatum and maintaining the growth of S. epidermidis (Figure 3(a) and Figure 3(b))
The Test Body Lotion with the triple biotic technology demonstrated a prebiotic effect in comparison to the Placebo Body Lotion by maintaining the growth of S. epidermidis, while inhibiting the growth of S. aureus (Figure 4(a) and Figure 4(b))
Summary
The nature of skincare and the cosmetic/personal care industry is rapidly changing with respect to the inclusion of new and novel constituents. In their review on the impact of prebiotics and probiotics on skin health, Al-Ghazzewi and Tester reported that prebiotics, when applied directly to skin, can selectively increase the activity and growth of beneficial skin microbiota. A clinical study conducted in patients with atopic dermatitis concluded that the use of a topically applied prebiotic was a novel therapeutic approach that could be used to enable normalization of skin microbiota. Many of these articles have focused on the impact of a single prebiotic due to the potential for more than one pre or probiotics to have interactions or increase the complexity of the study
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