Abstract
Synthetic sensing materials (artificial receptors) are some of the most attractive components of chemical/biosensors because of their long-term stability and low cost of production. However, the strategy for the practical design of these materials toward specific molecular recognition in water is not established yet. For the construction of artificial material-based chemical/biosensors, the bottom-up assembly of these materials is one of the effective methods. This is because the driving forces of molecular recognition on the receptors could be enhanced by the integration of such kinds of materials at the ‘interfaces’, such as the boundary portion between the liquid and solid phases. Additionally, the molecular assembly of such self-assembled monolayers (SAMs) can easily be installed in transducer devices. Thus, we believe that nanosensor platforms that consist of synthetic receptor membranes on the transducer surfaces can be applied to powerful tools for high-throughput analyses of the required targets. In this review, we briefly summarize a comprehensive overview that includes the preparation techniques for molecular assemblies, the characterization methods of the interfaces, and a few examples of receptor assembly-based chemical/biosensing platforms on each transduction mechanism.
Highlights
Molecular recognition systems in organisms contribute to the tuning of biological functions [1].For instance, enzymes which have substrate specificity can catalyze highly efficient and selective biochemical reactions under ambient temperature and pressure conditions
We have provided an overview of the various chemical/biosensing platforms functionalized with synthetic receptor membranes ranging from the basic strategy for materials design to sensing applications
Encouraged by this effective strategy for molecular recognition in nature, the bottom-up integration of synthetic receptors as the membranes at the interfaces has been employed for enhancing the sensing ability of artificial materials
Summary
Molecular recognition systems in organisms contribute to the tuning of biological functions [1]. Bottom-up integration of the receptors as the preparation of artificial receptor-based sensors for practical applications is still in its initial stages, molecular assemblies is considered as one of the most useful approaches for the construction of since the analyte specificity of most of the artificial materials is generally lower than that of biomaterials selective sensing fields for analytes. In. In this review, we briefly summarize a research overview including the construction methods of addition, the driving forces in molecular recognition (i.e., noncovalent interactions) can be amplified molecular assemblies, the characterization techniques for the interfaces, and the rational design and at the interfaces such as the boundary portion between the liquid and solid phases [9,10].
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