Abstract
The effects of 4-aminopyridine on adrenergic transmission in rabbit vas deferens were investigated. 10 −5–10 −3 M 4-aminopyridine markedly potentiated the sustained, secondary contractile response to transmural stimulation and significantly increased the amount of (±)-[ 3H]-metaraminol released at 5 Hz, but had little effect on responses to exogenous (−)-noradrenaline. 10 −5–10 −4 M 4-aminopyridine did not significantly alter the accumulation or efflux of (−)-[ 3H]-noradrenaline in rabbit heart. It is suggested that 4-aminopyridine potentiated responses of rabbit vas deferens to transmural stimulation mainly by increasing transmitter release, possibly as a result of prolongation of the action potential. Responses to transmural stimulation were also potentiated by 2- and 3-aminopyridine and by 3,4-diaminopyridine but not by pyridine, aniline, 4-dimethylaminopyridine, 4-aminoethylpyridine or 2-aminopyrimidine.
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