The potential value of red blood cell distribution width in patients with invasive hydatidiform mole.

Lingling Zhang,Lingling Zhan,Youjun Xie

doi:10.1002/jcla.22846

Abstract

BackgroundRed blood cell distribution width (RDW) has attracted increasing attention in cancer. The aim of this study was to assess the changes of RDW in patients with invasive hydatidiform mole and analyze the relationship between RDW and invasive hydatidiform mole.MethodsA retrospective analysis was performed on 102 patients diagnosed as invasive hydatidiform mole in the First Affiliated Hospital of Guangxi Medical University from January 2009 to March 2018. A total of 120 healthy subjects were used as a control group. The Mann‐Whitney U test was used for comparison between the invasive hydatidiform mole and control groups. Comparison of RDW with other blood parameters was performed using Spearman's. The area under the ROC curve (AUC) and 95% confidence interval (95% CI) were also determined.ResultsThe RDW, platelet‐lymphocyte ratio (PLR), neutrophil‐lymphocyte ratio (NLR), and absolute lymphocyte count were significantly elevated in the invasive hydatidiform mole group compared with control group. The hemoglobin (Hb) concentration, mean red blood cell volume (MCV) and platelet count (PLT) were significantly lower in invasive hydatidiform mole group than control group. Grade III and above invasive hydatidiform mole patients had higher levels of RDW than grade I and II patients. Correlation analysis showed that RDW was negatively correlated with Hb, MCV, NLR, and neutrophil count, but positively correlated with PDW and different stages of invasive hydatidiform mole. The ROC curve showed that the AUC of the RDW was 0.660 (95% CI 0.581‐0.740; P < 0.01).ConclusionThis study reveals the potential value of RDW in invasive hydatidiform mole.

Highlights

Invasive hydatidiform mole is a malignant tumor originating from tro‐ phoblastic tissue
A total of 2 mL venous blood sample was collected from each patient who was first diagnosed as an invasive hydatidiform mole and did not receive any treatment in the morning blood draw
The results showed that the level of Red blood cell distribution width (RDW), abso‐ lute lymphocyte count, neutrophil‐lymphocyte ratio (NLR), and platelet‐lymphocyte ratio (PLR) was significantly higher in the invasive hydatidiform mole group compared with the control group (P < 0.05)

Summary

Introduction

Invasive hydatidiform mole is a malignant tumor originating from tro‐ phoblastic tissue. Invasive hydatidiform moles occur in approx‐ imately 15% of patients with complete hydatidiform moles, while in other types of pregnancies it occurs less frequently. It may pene‐ trate the myometrium to cause localized hemorrhagic necrosis.[2]. Invasive hydatidiform mole has ma‐ lignant tumor behavior and can undergo extensive metastasis.[3]. Results: The RDW, platelet‐lymphocyte ratio (PLR), neutrophil‐lymphocyte ratio (NLR), and absolute lymphocyte count were significantly elevated in the invasive hy‐ datidiform mole group compared with control group. The hemoglobin (Hb) concen‐ tration, mean red blood cell volume (MCV) and platelet count (PLT) were significantly lower in invasive hydatidiform mole group than control group. Conclusion: This study reveals the potential value of RDW in invasive hydatidiform mole

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